How to support detox pathways with food

Detox is a naturopathic protocol that can be really helpful to restore effective function. Its basic aim is to assist your liver and kidneys so that they can remove toxins that you are exposed to in your diet and through your environment. Typically detox is recommended to support clients when they struggle with hormonal imbalance, find it difficult to lose weight or are suffering from allergies or poor digestive health.

The liver is responsible for processing food and a range of substances that we are exposed to through our diet and lifestyle. There are three phases and six pathways that support our ability to remove toxins from the body and in this blog you will find out how to support them with food. These processes convert toxins which are usually fat soluble into water soluble substances which can then be excreted through sweat, urine or stool.

First up what are the three phases and what do they do? The first phase uses enzymes called Cytochrome P450 to modify substances which produces free radicals. The second phase detoxifies these substances so they can be removed from the body. This relies on the six pathways known as Methylation, Glucoronidation, Sulfation, Acetylation, Glutathione Conjugation and Glycination. These are the pathways we can support with either food or supplements.

The third phase reduces our toxic load within the Small Intestine and supports the elimination of xenobiotics (hormone like substances).

Supporting these six pathways for detoxification requires a range of nutrients so lets focus on what foods are most helpful for you.

  1. Methylation

This process involves adding a methyl group made up of Carbon with three Hydrogen atoms. This makes the substance water soluble. The process requires B vitamins but in particular folic acid or folate. Good sources of folate include dark green vegetables such as leafy greens and asparagus.

2. Glucoronidation

This pathway is particularly important as it metabolises about 35% of the drugs prescribed and it requires the body to produce glucuronic acid. Fish oils and limonene which is found in citrus peel may activate this pathway. Ideally oily fish are a good source but the preference would be to use small oily fish like sardines. Green tea is also a good promoter of this pathway ideally try and use organic options as much as possible.

3. Sulfation

This pathway is critical for detoxifying steroid hormones, bile acids and neurotransmitters. Sulfation requires sulfur containing amino acids which are usually found in protein containing foods. In addition an adequate level of molybdenum is required. The best sources of molybdenum are found in legumes such as chickpeas, lentils and beans. For some people who don’t tolerate legumes, nuts and liver are other good quality sources.

4. Acetylation

Vitamin B1, B5 and Vitamin C are essential for this phase. Good quality sources of Vitamin C include citrus fruits and in particular oranges. Brightly coloured vegetables, such as capsicum, and berrries such as strawberries are also good Vitamin C sources.

5. Glutathione Conjugation

Glutathione is an important antioxidant for the liver as well as supporting conjugation through the liver. Glutathione is made up of three peptides glutamine, cysteine and glycine. It is also activated by sulphorophane which is found in brassica vegetables, like cabbage and broccoli sprouts. Cabbage is also high in glutamine.

6. Glycination

This process involves the addition of amino acids to aid in the process of conjugation. Diets low in protein often result in a reduction in our ability to eliminate toxins. Good quality protein sources are important to assist in this pathway and this does include both meat based protein as well as vegetarian options such as legumes, tofu and eggs.

Ultimately supporting effective detoxification requires good quality protein sources, green leafy, multi coloured and brassica vegetables as well as legumes and fruit like berries.

If you would like more information on detoxification, or simply to understand if it can assist you, join me online for my detoxification webinar series. The next program opens on the 28th October and you can book in on this link . Alternatively if you would like to discuss how whether detox is appropriate for you you can make an appointment on (02) 8084 0081 or online.

For more blogs on detoxification you might like to read the following;

  1. Getting ready to detox
  2. Detoxing is it for me?
  3. What are the best vegetables for feeding your gut?

Menopause could be a report card

shutterstock_258522395One of the myths about menopause is that symptoms are related to a deficiency of hormones, either estrogen or progesterone. Yet if that was the case why wouldn’t all women get these symptoms ? My favourite assessment of menopause is that its a “report card” on the last 10 years. That’s great if you have been doing all the right things but it can be problematic if you live in a big city, work full time with kids or have dealt with a  lot of stress.

Generally in practice the consistent triggers for menopausal havoc are adrenal fatigue, toxicity, dysbiosis (gut dysfunction), hormonal imbalance, excess weight and inflammation. In the more difficult cases it can be a combination of these factors and that’s why its important to ensure you review all these areas in your initial case taking and think about which areas you need to prioritise.

So how do you decide what’s contributing to your symptoms ?

  1. Adrenal Fatigue – also known as I am a full time carer, full time worker and full time nanny/housekeeper (also known as Mum) or combination of some or all of the above. Stress initially raises adrenaline to prepare us for fight or flight. Longer term it results in elevated cortisol which may result in fluid retention and weight gain.
  2. Dysbiosis or gut dysfunction – if your gut isn’t working properly its hard to digest the nutrients you need and also support your liver to detoxify effectively. This will result in hormone imbalance particularly through peri-menopause when the liver is already working harder to detoxify hormones. Signs of gut dysfunction could include flatulence, bloating or reflux. Treatment will often involve identifying and removing food intolerances whilst supporting digestive function to reduce reactivity.
  3. Toxicity – two big areas areas are Heavy Metals or Endocrine Disruptors which can be a little tricky to determine but think lots of plastics or old fillings (usually amalgams contain mercury and silver). Switch over to glass or BPA free plastic as much as possible to reduce your exposure to endocrine disruptors. Also look at your cosmetics and skin care products to ensure you are minimising your exposure to chemicals and reducing the burden on the liver. One problem with toxicity is that it makes it harder to lose weight as the body will push these toxins into fat and will resist releasing it to protect you.
  4. Inflammation can be due to carrying excess body fat but can also be due to chronic injuries which trigger constant inflammation in the body. Anti-inflammatory supplements such as fish oil and tumeric can be helpful but exercise has an important role to play here in reducing inflammation as well. Just make sure its not aggravating an existing injury and consider whether you may need more support such as in acqua aerobics in the pool for example which can take pressure off joints.
  5. Hormonal Imbalance for some women hormones will be imbalanced because of some of the reasons listed above however there are some good herbal and homeopathic options available which can help. The most widely used herbal medicine is probably Vitex or Agnes Castus which can assist women with menopausal symptoms. Usually with herbal medicine and certainly with homeopathic medicines it is preferable to prescribe based on the client’s specific symptoms. In the last few months I have found clients have had relief from symptoms with Glonoine, Sepia and Sulphur homeopathically, its never one size fits all . A 2008 study of 438 women with hot flushes showed a significant improvement in symptoms for 90% of women in the trial (1).

Christine Pope is a Naturopath and Nutritionist based at Elemental Health at St Ives. Appointments can be made on 8084 0081 or online at the website

 

 

(1) Treating Hot Flushes in Menopausal Women – an observational study accessed at https://www.ncbi.nlm.nih.gov/pubmed/18194760